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3 edition of Bioassay of p-phenylenediamine dihydrochloride for possible carcinogenicity. found in the catalog.

Bioassay of p-phenylenediamine dihydrochloride for possible carcinogenicity.

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Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Testing Program in Bethesda, Md .
Written in English

    Subjects:
  • Carcinogens.,
  • Dyes and dyeing -- Toxicology.,
  • Phenylenediamine -- Toxicology.

  • Edition Notes

    SeriesCarcinogenesis technical report series ; no. 174, DHEW publication ; no. (NIH) 79-1730, DHEW publication -- no. (NIH) 79-1730.
    The Physical Object
    Pagination101 p. in various pagings :
    Number of Pages101
    ID Numbers
    Open LibraryOL18014053M

    PATIENT INFORMATION SHEET N-Isopropyl-N-phenylphenylenediamine (IPPD) (I) Your patch testing results indicate that you have a contact allergy to N-Isopropyl-N-phenylphenylenediamine (IPPD). It is important that you familiarize yourself with this chemical and take steps to . Jun 12,  · A disclosed method of preparing p-phenylenediamine includes the steps of: reacting urea and nitrobenzene with a base in the presence of a polar solvent to yield 4-nitrosoaniline and 4-nitroaniline; and subsequently, diluting the resulting mixed solution in an alcohol and performing hydrogenation using a catalyst, thereby providing highly pure p-phenylenediamine destitute of an . Carcinogenicity IARC: No component of this product present at levels greater than or equal to % is identified as probable, possible or confirmed human carcinogen by IARC. ACGIH: No component of this product present at levels greater than or equal to % is identified as a carcinogen or potential carcinogen by ACGIH. 2. The acute toxicity reported on this page is of the pure chemical ingredient only and may not reflect the acute toxicity of individual pesticide products. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above. Cancer Information: 2,4-D IARC Carcinogens U.S. NTP Carcinogens.


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Bioassay of p-phenylenediamine dihydrochloride for possible carcinogenicity. by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Download PDF EPUB FB2

Get this from a Bioassay of p-phenylenediamine dihydrochloride for possible carcinogenicity. book. Bioassay of p-phenylenediamine dihydrochloride for possible carcinogenicity. [National Cancer Institute (U.S.).

Division of Cancer Cause and Prevention.]. A bioassay of p-phenylenediamine dihydrochloride for possible. carcinogenicity wa conductes d using Fische 34r4 rats and B6C3F1 mice. p-Phenylenediamin dihydrochloridee was administere idn the.

feed, at either of two concentrations t,o groups of 50 male and female animal osf each species Th. higeh and low concentration s. N-PHENYL-p-PHENYLENEDIAMINE FOR POSSIBLE CARCINOGENICITY. CAS No 2. N-PHENYL-p-PHENYLENEDIAMINE FOR POSSIBLE CARCINOGENICIT Y. It is conclude tha undedt thr conditione Bioassay of p-phenylenediamine dihydrochloride for possible carcinogenicity.

book thifs s bioassay, N-phenyl-p-phenylenediamine was no carcinogenit fo Fischecr 34r 4 rats or for B6C3F1 mice. National Cancer Institute. Bioassay of p-Phenylenediamine Dihydrochloride for Possible Carcinogenicity (CAS No.

TR U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health. American Conference of Governmental Industrial Hygienists (ACGIH).

TLVs and BEIs. Myhr, B.C., and Caspary, W.J. Evaluation of the LY mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, I.

Bioassay of Bioassay of p-phenylenediamine dihydrochloride for possible carcinogenicity. book sulfate for possible carcinogenicity Item Preview Bioassay of 2-chloro-p-phenylenediamine sulfate for possible carcinogenicity by National Cancer Institute (U.S.).

Division of Cancer Cause and Prevention. Publication date Pages: Opinion on p-phenylenediamine _____ 9 Function and uses p-Phenylenediamine is used as an ingredient of oxidative hair colouring products at a maximal Bioassay of p-phenylenediamine dihydrochloride for possible carcinogenicity.

book of %, which after mixing in a ratio with hydrogen peroxide prior to use, corresponds to a maximal concentration of % at application to the hair. Author(s): Litton-Bionetics, inc.; Carcinogenesis Testing Program (U.S.); National Institutes of Health (U.S.) Title(s): Bioassay of p-phenylenediamine.

Skin sensitization: Evidence Bioassay of p-phenylenediamine dihydrochloride for possible carcinogenicity. book p-phenylenediamine is a strong potential skin sensitizer., A German study showed that it was the 5 th most common skin allergen and that it had about a 5% sensitization rate.

Cancer: Aromatic amines found in hair dyes, such as p-phenylenediamine, have long been suspected of being lombardspirit.com example, they are linked to increased incidence of bladder. Carcinogenicity of an oxidation product of p-phenylenediamine.

Rojanapo W, Kupradinun P, Tepsuwan A, Chutimataewin S, Tanyakaset M. para-Phenylenediamine (p-PD), a widely used aromatic amine in the preparation of commercial oxidative-type hair dyes, has been previously demonstrated to have neither mutagenic activity to Salmonella typhimurium Cited by: SCCP//06 Opinion on p-phenylenediamine _____ 3 1.

BACKGROUND Submission I for p-Phenylenediamine was submitted in December by COLIPA1,2. Submission II for p-Phenylenediamine was submitted in March by COLIPA2. The Scientific Committee on Cosmetology (SCC) has at its 48th meeting on 4 October p-Phenylenediamine (PPD) is an organic compound with the formula C 6 H 4 (NH 2) 2.

This derivative of aniline is a white solid, but samples can darken due to air oxidation. It is mainly used as a component of engineering polymers and composites like kevlar.

It is also an ingredient in hair dyes and is occasionally used as a substitute for hennaChemical formula: C₆H₈N₂. National Cancer Institute (h) Bioassay of 2-chloro-p-phenylenediamine sulfate for possible carcinogenicity.

Bethesda, MD. Public Health Service, National Institutes of Health, National Cancer Institute. (Carcinogenesis, Technical Report Series No ) [DHEW Publication No Cited by: 1.

* p-Phenylenediamine may cause an asthma-like allergy. Future exposure can cause asthma attacks with shortness of breath, wheezing, cough, and/or chest tightness. * p-Phenylenediamine may damage the liver and kidneys. IDENTIFICATION p-Phenylenediamine is a white to slightly red, crystalline substance.

It is used in the manufacture of hair and other. 2-Chloro-p-phenylenediamine sulfate: All Experiments and Citations in CPDB The definition of each code in the plot below will appear in a pop-up window when the field name in the header line is clicked, e.g., Strain, Site, Path.

Nov 06,  · p-Phenylenediamine, the allergen of the year. Why now. Granted, p-phenylenediamine (PPD) has been the leading permanent hair coloring agent or. May 01,  · p-Phenylenediamine is a cosmetic hair dye intermediate used in permanent hair coloring products at concentrations of up to 5 percent (diluted with an oxidizing agent prior to application).

The extensive animal toxicity test data on p-Phenylenediamine and permanent cosmetic hair dyes containing this compound show that the degree of toxicity varies with concentration, test system and animal. Find here P-Phenylenediamine, Paraphenylenediamine manufacturers, suppliers & exporters in India.

Get contact details & address of companies manufacturing and supplying P-Phenylenediamine, Paraphenylenediamine, 1 across India. Here is what I read "1,4-Diaminobenzene [] (p-phenylenediamine) has been the main primary intermediaoutputte used worldwide for more than a years but has nowbeen largely replaced by 2,5-diaminotoluene" The source is ref 2 ("Hair Preparations" in Ullmann's Encyclopedia).

Usually a. N,n-dimethyl-p-phenylenediamine found in: N,N-Dimethyl-p-phenylenediamine Oxalate, N,N-Dimethyl-p-phenylenediamine Dihydrochloride, N,N-Dimethyl-p. You have no items in your cart. My Favorites List.

My Quotes. View Cart Details PROCEED TO CHECKOUT. By continuing to use this site, you agree to the use of cookies. Jun 06,  · A Historical Perspective on Para-phenylenediamine “No, you must keep your good looks.

We live in an age that reads too much to be wise, and that thinks too much to be beautiful. We cannot spare you.” 9. The deleterious emphasis on youth and beauty is no more evident than in the moral fantasy of The Picture of Dorian Gray by Oscar Wilde.

p-Phenylenediamine Dihydrochloride is an aromatic diamine and precursor to several heterocyclic compounds. Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for 5/5(7). Alfa Aesar is a leading manufacturer and supplier of research chemicals, pure metals and materials for a wide span of applications.

Ask your hairdresser for dyes free of p-phenylenediamine. Hairdressers shuold use vinyl gloves to protect hands from contact when using hair dyes.

Check for use in dark colored clothing (blue, black or brown). Individuals that have sensitivity to this chemical may also cross react with PABA containing sunscreens, Benzocaine and "sulfa" drugs.

No evidence of carcinogenicity was observed in a dietary study N-Phenyl-p-Phenylenediamine. Irritation and sensitization were both observed, but no ocular irritation was seen following exposure to N-Phenyl-p-Phenylenediamine.

Clinical data indicated that N-Phenyl-p-Phenylenediamine was a skin irritant and a sensitizer in some individuals. N,N,N′,N′-tetramethyl-p-phenylenediamine dihydrochloride (TMPD) is an oxidizable compound that serves as a reducing co-substrate for heme peroxidases.

It is also used as a test reagent in microbiology for the classification of cytochrome oxidase positive aerobic lombardspirit.com: p-phenylenediamine - CAS # Information provided on p-phenylenediamine () is for reference only and is subject to change.

There is no warranty of accuracy or completeness of any information contained herein. How is paraphenylenediamine allergy diagnosed. PPD allergy may be suspected clinically and is confirmed by patch lombardspirit.comts having a clear history of allergy to hair dye or black henna tattoos are best tested with a lower % PPD concentration than in the baseline series of allergens, to avoid a severe blistering patch test reaction.

There are two methods of patch testing. May 09,  · Ingredient Watch List: Phenylenediamine, the Hair Dye Allergen That Can Irritate Skin. May 9, p-phenylenediamine, or 1,4-benzenediamine, PPD is an organic compound used in hair dyes, as well as in rubber chemicals, textile dyes and pigments.

I read about a hair dye from Germany called Logona in a book called Healthy Beauty by Epstein, a. Nov 06,  · In contrast, reactions caused by occupational exposure appear to be increasing. Comparing the periods of to and toa. Type of substance Composition: mono-constituent substance Origin: organic Total tonnage band Total range: 10 - tonnes per annum REACH Registered as.

This negative result was RESULTS M utagenicity of p-phenylenediamine preparations A C Q ji 4 II 2 I I 3 / 9 1 v I I 2 J 10 5 O C ~O t 1W 10 5 Fig. Silica-gel column chromatography of (A) the oxidation mixture prepared from p-phenylenediamine and resorcinol and (B) the acetylated lombardspirit.com by: Para Phenylenediamine.

p- Phenylenediamine (PPD) is an organic compound with formula C 6 H 4 (NH 2) 2. PPD is an ingredient found in most hair dye and primarily used as a dye intermediate and as a dye.

PPD is a derivative of paranitroaniline, and used for dyeing furd, photochemical measurements, accelerating vulcanization and azo-dye manufacturing as well as for oxidizing hair dyes. p-Phenylenediamine is used as a raw material to produce dyes (particularly hair dyes and dyes used for dyeing furs), photographic developing agents, polymers and fibers, and curing agents for high temperature composites.

SALES SPECIFICATION: APPEARANCE. A scheme for ranking the quantitative activity of chemical carcinogens is described. This activity scheme uses as its base, dose potency measured as TD 50, the chronic dose rate that actuarially halves the adjusted percentage of tumor-free animals at the end of the study (Gold et al., lombardspirit.com Perspect., 67, –, ).Cited by: An accurate determination of the correlation between the carcinogenicity and the mutagenicity of chemicals has been hampered by the lack of a well-documented list of noncarcinogens.

N-Methyl-p-phenylenediamine dihydrochloride - CAS # Information provided on N-Methyl-p-phenylenediamine dihydrochloride () is for reference only and is subject to change. There is no warranty of accuracy or completeness of any information contained herein.

Sep 05,  · lombardspirit.com provides accurate and independent information on more than 24, prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

Data sources include IBM Watson Micromedex (updated 3 Feb ), Cerner Multum™ (updated 5 Feb ). Chemicals such as p-phenylenediamine, ammonia, and lead acetate used on the scalp and left on for 30 minutes or more will inevitably soak into the skin, wind up in the blood supply and spread their toxic effects throughout the body.

There ARE Alternatives to Dangerous Chemical Hair Coloring. After sampling for 4 h at 1 L/min, the filters were analyzed. None of the amines were found on the back filter and approximately, and µg of m- o- and p-phenylenediamine respectively were found on the front filter. This corresponds to air concentrations of, and mg/m 3 for m- o- and p-phenylenediamine respectively.

N,N'-BIS(1,4-DIMETHYLPENTYL)-P-PHENYLENEDIAMINE pdf react with oxidizing agents (NTP, ). Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.Type of substance Composition: mono-constituent substance Origin: organic Other names Trade names: 1,4-Benzenediamine, N-(1-methylethyl)-N'-phenyl.The black rubber mix ingredients are less common in products ebook home use, but they may be ebook in certain types of rubber articles.

At home, you may find black rubber mix or one of its components in: • Household products made with black rubber such as masks and goggles, shoes and tires, watchbands, underwear elastic, stockings, dental tips.